ANTACIDS AND NSAIDS - DIFLUNISAL

Antacids containing aluminium with or without magnesium can reduce the absorp- tion of diflunisal by up to 40%, but no important interaction occurs if food is taken at the same time. Magnesium hydroxide can increase the rate of diflunisal absorption, which may improve the onset of analgesia.
If diflunisal is taken with or after food as advised, it appears that this interaction should have little clinical relevance.
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