ANTACIDS AND LEVODOPA

Antacids do not appear to interact significantly with immediate release levodopa, but they may reduce the bioavailability of modified release preparations of levodopa (e.g. A MadoparCR).
Concurrent use need not be avoided with standard preparations. With modified- release preparations it would seem advisable to avoid concurrent administration (2 to 3 hours is usually enough in other similar situations). The outcome should be monitored.
(47)
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