An aluminium/magnesium hydroxide antacid given with or 2 hours after
gabapentin reduced its bioavailability by about 20%. When the antacid was given 2 hours before
gabapentin, the bioavailability was reduced by about 10%.
These small changes are unlikely to be of
clinical importance. However, the manufacturer recommends that
gabapentin is taken about 2 hours after alumin- ium/magnesium-containing
antacids.