An aluminium/magnesium hydroxide antacid given with or 2 hours after gabapentin reduced its bioavailability by about 20%. When the antacid was given 2 hours before gabapentin, the bioavailability was reduced by about 10%.
These small changes are unlikely to be of clinical importance. However, the manufacturer recommends that gabapentin is taken about 2 hours after alumin- ium/magnesium-containing antacids.
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