Both aluminium hydroxide and aluminium/magnesium hydroxide can cause a small reduction in the absorption of ethambutol (e.g. AUC decreased by 10%) in some patients.
The reduction in absorption is generally small and variable, and it seems doubtful if it will have a significant effect on the treatment of tuberculosis. However, the US manufacturer suggests that aluminium hydroxide-containing antacids should not be taken until 4 hours after a dose of ethambutol.
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