The effective disintegration, dissolution and eventual absorption of dipyridamole in tablet or suspension form depends upon having a low pH in the stomach. Drugs that raise the gastric pH are expected to reduce the bioavailability of dipyridamole.
The clinical significance of this possible interaction is unknown. Note that Modified-release preparations of dipyridamole (that are buffered) do not appear to be affected. For other preparations, consider separating the dosing by 2 to 3 hours, as this minimises other absorption interactions with antacids.
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