The effective disintegration, dissolution and eventual absorption of
dipyridamole in tablet or suspension form depends upon having a low pH in the stomach. Drugs that raise the gastric pH are expected to reduce the bioavailability of
dipyridamole.
The
clinical significance of this possible interaction is unknown. Note that Modified-release preparations of
dipyridamole (that are buffered) do not appear to be affected. For other preparations, consider separating the dosing by 2 to 3 hours, as this minimises other absorption interactions with
antacids.