Although some studies suggest that antacids can reduce the bioavailability of digoxin, there is other evidence suggesting that no clinically relevant interaction occurs.
Separating the dosages by 1 to 2 hours to minimise admixture is effective with many other drugs that interact with antacids. However, unless further information becomes available it seems unlikely that separating administration is necessary, although it may be worth bearing in mind if, on rare occasions, a patient seems to experience an interaction.
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