Although some studies suggest that antacids
can reduce the bioavailability of digoxin
, there is other evidence suggesting that no clinically relevant interaction occurs.
Separating the dosages by 1 to 2 hours to minimise admixture is effective with many other drugs that interact with antacids
. However, unless further information becomes available it seems unlikely that separating administration
is necessary, although it may be worth bearing in mind if, on rare occasions, a patient seems to experience an interaction.