Although some studies suggest that
antacids can reduce the bioavailability of
digoxin, there is other evidence suggesting that no clinically relevant interaction occurs.
Separating the dosages by 1 to 2 hours to minimise admixture is effective with many other drugs that interact with
antacids. However, unless further information becomes available it seems unlikely that separating
administration is necessary, although it may be worth bearing in mind if, on rare occasions, a patient seems to experience an interaction.