Aluminium/magnesium hydroxide has been shown to reduce the bioavailability of
cefpodoxime proxetil by about 40%. Sodium bicarbonate and aluminium hydroxide seem to have similar effects.
It has been recommended that
cefpodoxime is given at least 2 hours apart from
antacids.
Other
cephalosporins Aluminium/magnesium hydroxide reduced the AUC of a modified-release preparation of
cefaclor by 18%, but this reduction is small and considered unlikely to be clinically important.
No action needed.