ANTACIDS AND CEPHALOSPORINS CEFPODOXIME

Aluminium/magnesium hydroxide has been shown to reduce the bioavailability of cefpodoxime proxetil by about 40%. Sodium bicarbonate and aluminium hydroxide seem to have similar effects.
It has been recommended that cefpodoxime is given at least 2 hours apart from antacids.
Other cephalosporins
Aluminium/magnesium hydroxide reduced the AUC of a modified-release preparation of cefaclor by 18%, but this reduction is small and considered unlikely to be clinically important.
No action needed.
(95)
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