Aluminium/magnesium hydroxide has been shown to reduce the bioavailability of cefpodoxime
proxetil by about 40%. Sodium bicarbonate and aluminium hydroxide seem to have similar effects.
It has been recommended that cefpodoxime
is given at least 2 hours apart from antacids
Aluminium/magnesium hydroxide reduced the AUC of a modified-release preparation of cefaclor
by 18%, but this reduction is small and considered unlikely to be clinically important.
No action needed.