salicylate concentrations of patients taking large doses of aspirin
or other salicylates as anti-inflammatory drugs can be reduced to subtherapeutic levels by aluminium/magnesium hydroxide or sodium bicarbonate antacids
Care should be taken to monitor serum
salicylate levels if any antacid is started or stopped in patients where the control
of salicylate levels is critical. Probably of little importance with small or one-off doses of aspirin
. Note that antacids
may also increase the rate of absorption of aspirin
given as enteric-coated tablets.