The serum salicylate concentrations of patients taking large doses of aspirin or other salicylates as anti-inflammatory drugs can be reduced to subtherapeutic levels by aluminium/magnesium hydroxide or sodium bicarbonate antacids.
Care should be taken to monitor serum salicylate levels if any antacid is started or stopped in patients where the control of salicylate levels is critical. Probably of little importance with small or one-off doses of aspirin. Note that antacids may also increase the rate of absorption of aspirin given as enteric-coated tablets.
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