Antacids containing aluminium/magnesium hydroxide or magnesium trisilicate can reduce the urinary excretion of chlorpromazine by up to 45%. Similarly, an aluminium/magnesium hydroxide antacid reduced the absorption of sulpiride. In vitro studies suggest that this interaction may possibly also occur with other antacids and phenothiazines.
The clinical importance of these interactions are not established, but it would seem reasonable to give chlorpromazine or sulpiride 2 to 3 hours after alum- inium/magnesium hydroxide antacids to minimise any interaction.
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