ANGIOTENSIN II RECEPTOR ANTAGONISTS AND TACROLIMUS

Candesartan and losartan do not affect the pharmacokinetics of tacrolimus. Concur- rent use with angiotensin II receptor antagonists may increase the risk of developing hyperkalaemia and/or nephrotoxicity in those taking tacrolimus.
Both renal function and potassium levels should be monitored if angiotensin II receptor antagonists are given with tacrolimus.
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