ANGIOTENSIN II RECEPTOR ANTAGONISTS AND RIFAMPICIN (RIFAMPIN)

Rifampicin reduces the levels of the active metabolite of losartan and the blood pressure lowering effects of losartan.
This interaction is by no means established, but monitor the effects of concurrent use on blood pressure. Consider raising the losartan dose or using an alternative to losartan if problems occur. Note that theoretically irbesartan and possibly candesartan may also be affected.
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