Studies have found no significant changes in
renal function in patients taking
ciclosporin with candesartan or losartan. There is a possible risk of hyperkalaemia if angiotensin II
receptor antagonists are given with ciclosporin, as both drugs may raise potassium levels.
Although
renal failure has not been seen with this combination note that cases have occurred with
ACE inhibitors. Monitor potassium levels more closely in the initial weeks of concurrent use.