ANGIOTENSIN II RECEPTOR ANTAGONISTS AND CICLOSPORIN (CYCLOSPORINE)

Studies have found no significant changes in renal function in patients taking ciclosporin with candesartan or losartan. There is a possible risk of hyperkalaemia if angiotensin II receptor antagonists are given with ciclosporin, as both drugs may raise potassium levels.
Although renal failure has not been seen with this combination note that cases have occurred with ACE inhibitors. Monitor potassium levels more closely in the initial weeks of concurrent use.
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