Low-dose
aspirin does not appear to affect the antihypertensive
efficacy of losartan and would therefore not be expected to alter the effects of other angiotensin II
receptor antagonists. High-dose
aspirin does not appear to have been studied.
No action needed if low-dose
aspirin is used. Suspect an interaction with high-dose
aspirin if the angiotensin-II
receptor antagonist seem less effective or blood pressure
control is erratic. Consider an alternative analgesic, but note that NSAIDs may also affect blood pressure
control.