1. The loss or weakening of the body's
immunity to an irritating agent, or
antigen. The strength of the body's
immune response is often quantitatively measured by means of a skin test where a solution containing an
antigen known to cause a response, such as mumps or
candida, is injected immediately under the skin. The lack of a reaction to these common antigens indicates anergy. See also
Antigen. 2. Researchers in cell culture have shown that CD4+T cells can be turned off by a signal from HIV that leaves them unable to respond to further
immune system stimulation. This inactivated state is known as anergy. See also
CD4 (
T4) or CD4+ Cells.