ANASTROZOLE

(an AS troe zole) Brand: Arimidex

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What is the most significant information I must know about anastrozole?

Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).

Do not use anastrozole if you are pregnant. It could harm the unborn child.

Anastrozole may not work as well if you take it together with estrogen medicine (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings).

Anastrozole may magnify your risk of a stroke or blood clot. Call your doctor at once if you have sudden numbness or weakness, (especially on one side of the body), sudden severe headache, slurred speech, or problems with vision or balance.

What is anastrozole?

Anastrozole lowers estrogen levels in postmenopausal women, which may slow the growth of determined types of breast tumors that need estrogen to grow in the body.

Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).

Anastrozole may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking anastrozole?

• You must not use this medicine if you are allergic to anastrozole, if you are breast-feeding a child, or if you have not yet completed menopause. Anastrozole is not for use in men or children.

• To create certain anastrozole is safety for you, speak your doctor if you have:

· heart disease;

· circulation problems;

· a history of stroke or blood clot;

· severe liver malady;

· tall cholesterol; or

· osteoporosis or low bone mineral density.

Anastrozole can decrease bone mineral density, which may magnify your risk of developing osteoporosis. Your bone mineral density may need to be tested till and during treatment with anastrozole.

• FDA pregnancy category D. Do not use anastrozole if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.

• It is not known whether anastrozole passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using anastrozole.

• You may need to take a pregnancy test till using anastrozole, to create certain you are not pregnant.

How must I take anastrozole?

Anastrozole is generally taken once for day. Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• You may take anastrozole with or without food.

• You may need to hold taking this medicine for up to 5 years. Follow your doctor's instructions.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking anastrozole?

• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.

Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of anastrozole?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· sudden numbness or weakness, especially on one side of the body;

· sudden severe headache, confusion, problems with vision, speech, or balance;

· a bone fracture;

· swollen glands;

· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· swelling in your hands or foots; or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• General side effects may include:

· weakness, hot flashes;

· joint pain or stiffness, problems with your fingers while gripping;

· sore throat, headache, back pain, bone pain;

· depression, mood changes, sleep problems (insomnia);

· mild nausea, vomiting; or

· mild rash.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect anastrozole?

Anastrozole may not work as well if you take it together with an estrogen medicine (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings). Till you start taking anastrozole, speak your doctor if you also take tamoxifen or estrogen.

• Another drugs may interact with anastrozole, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Speak every of your health care providers about all medicines you use now and any medication you start or stop using.

Where can I get more information?

• Your pharmacist can provide more information about anastrozole.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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