There is evidence that acute
renal failure and electrolyte disturbances (e.g. hypomagnesaemia) may develop in patients taking amphotericin B if they are also given
parenteral pentamidine: both drugs are known to be
nephrotoxic. See also drugs that prolong the QT interval.
No interaction seems to occur when
pentamidine is given by inhalation, probably because the
serum levels achieved are low. Increased monitoring of
renal function would be appropriate if both drugs are used.