AMPHOTERICIN B AND PENTAMIDINE

There is evidence that acute renal failure and electrolyte disturbances (e.g. hypomagnesaemia) may develop in patients taking amphotericin B if they are also given parenteral pentamidine: both drugs are known to be nephrotoxic. See also drugs that prolong the QT interval.
No interaction seems to occur when pentamidine is given by inhalation, probably because the serum levels achieved are low. Increased monitoring of renal function would be appropriate if both drugs are used.
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