Amphotericin B may cause hypokalaemia, which can be severe. Although there seem to be no reports of adverse interactions, it would be logical to expect that digitalis toxicity could develop in patients given both drugs if the potassium levels fall. Amiloride has been successfully used to counteract the potassium loss caused by amphotericin B.
Potassium levels should be monitored when amphotericin B is given, but extra care is needed in those taking digoxin. Supplement potassium or prevent its loss as appropriate.
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