A rise in
amiodarone levels of about 50% has been seen in a patient given indinavir. Other
protease inhibitors would be expected to interact similarly.
The concurrent use of
amiodarone with a
protease inhibitor is generally contraindicated. However, in the UK the exception is
atazanavir, and in the US, caution and increased monitoring, including taking
amiodarone levels, is recom- mended with
amprenavir,
atazanavir, fosamprenavir, and lopinavir.