A rise in amiodarone
levels of about 50% has been seen in a patient given indinavir. Other protease inhibitors
would be expected to interact similarly.
The concurrent use of amiodarone
with a protease
inhibitor is generally contraindicated. However, in the UK the exception is atazanavir
, and in the US, caution and increased monitoring, including taking amiodarone
levels, is recom- mended with amprenavir
, fosamprenavir, and lopinavir.