AMIODARONE AND LIDOCAINE

Isolated reports describe a seizure in a man taking lidocaine about 2 days after he started to take amiodarone, and sinoatrial arrest in another man with sick sinus syndrome who was given both drugs. There is conflicting evidence as to whether or not amiodarone affects the pharmacokinetics of lidocaine.
Careful monitoring is required if both drugs are used.
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