Patients taking levothyroxine for hypothyroidism may develop elevated levels of thyroid-stimulating hormone or overt hypothyroidism when also given amiodarone.
The manufacturer of amiodarone contraindicates its use in patients with evidence or a history of thyroid dysfunction and recommends thyroid function tests in all patients before starting amiodarone. Levothyroxine has been given to correct hypothyroidism induced by amiodarone. Close monitoring is required if amiodarone is given with levothyroxine.
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