Patients taking
levothyroxine for hypothyroidism may develop elevated levels of thyroid-stimulating hormone or overt hypothyroidism when also given
amiodarone.
The manufacturer of
amiodarone contraindicates its use in patients with evidence or a history of
thyroid dysfunction and recommends
thyroid function tests in all patients before starting
amiodarone.
Levothyroxine has been given to correct hypothyroidism induced by
amiodarone. Close monitoring is required if
amiodarone is given with
levothyroxine.