Serum
flecainide levels are increased by about 50% by
amiodarone. An isolated report describes torsade de pointes in a patient taking
amiodarone with
flecainide.
Reduce the
flecainide dosage by one-third to one-half if
amiodarone is added and monitor for
flecainide adverse effects. The interaction may take 2 weeks or more to develop fully.