AMIODARONE AND FLECAINIDE

Serum flecainide levels are increased by about 50% by amiodarone. An isolated report describes torsade de pointes in a patient taking amiodarone with flecainide.
Reduce the flecainide dosage by one-third to one-half if amiodarone is added and monitor for flecainide adverse effects. The interaction may take 2 weeks or more to develop fully.
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