AMIODARONE AND COLESTYRAMINE

Colestyramine appears to reduce the serum levels of amiodarone by about 50%.
Because amiodarone undergoes some enterohepatic recirculation, separating the doses may only minimise the interaction. Monitor for decreased amiodarone effects if colestyramine is started, and adjust the amiodarone dose as necessary, or consider an alternative to colestyramine.
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