AMIODARONE AND CICLOSPORIN (CYCLOSPORINE)

Ciclosporin serum levels can be increased by amiodarone and nephrotoxicity has occurred as a result. Increased amiodarone levels and pulmonary toxicity have been reported in patients also given ciclosporin.
Ciclosporin levels and/or effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if amiodarone is started or stopped. Adjust the dose of ciclosporin as necessary. The significance of the increase in amiodarone levels and the occurrence of pulmonary toxicity is unclear but bear these reports in mind in case of unexpected effects.
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