Hypotension, bradycardia, ventricular fibrillation and asystole have been seen in a few patients given amiodarone
with propranolol, metoprolol or sotalol
, see also drugs that prolong the QT interval). However, analysis of clinical
studies suggests that the combination can be beneficial.
The concurrent use of beta blockers
is not uncommon and may be therapeutically useful. However, concurrent use should be undertaken with caution and an appreciation of the potential adverse effects, especially with sotalol