Hypotension, bradycardia, ventricular fibrillation and asystole have been seen in a few patients given amiodarone with propranolol, metoprolol or sotalol (for sotalol, see also drugs that prolong the QT interval). However, analysis of clinical studies suggests that the combination can be beneficial.
The concurrent use of beta blockers and amiodarone is not uncommon and may be therapeutically useful. However, concurrent use should be undertaken with caution and an appreciation of the potential adverse effects, especially with sotalol.
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