Hypotension, bradycardia, ventricular fibrillation and asystole have been seen in a few patients given
amiodarone with propranolol, metoprolol or
sotalol (for
sotalol, see also drugs that prolong the QT interval). However, analysis of
clinical studies suggests that the combination can be beneficial.
The concurrent use of
beta blockers and
amiodarone is not uncommon and may be therapeutically useful. However, concurrent use should be undertaken with caution and an appreciation of the potential adverse effects, especially with
sotalol.