Aminophylline (Somophyllin, Truphylline); Bronchodilator; Inj: 25 mg/mL
Liq: 105 mg/5 mL
Tab: 100, 200 mg
Tab CR: 225 mg;
IV Loading dose: 5-6 mg/kg
IV over 20-30 minutes
Maintenance IV infusion: 1-6 mos: 0.5 mg/kg/hr
6-12 mos: 0.6-0.75 mg/kg/hr
12 mos-10 yrs: 1.0 mg/kg/hr
10-16 yrs: 0.75-0.9 mg/kg/hr
>16 yrs: 0.7 mg/kg/hr
Oral dose:
1-9 yrs: 16-19.2 mg/kg/day q6-12h
9-12 yrs: 12.8 mg/kg/day q6-12h
12-16 yrs: 10.4 mg/kg/day q6-12h
>16 yrs: 8 mg/kg/day q6-12h
Liq or tab: q6-8h; CR tab: q8-12h
Therapeutic Levels: 10-20 mcg/mL.
Aminophylline contains 80%
theophylline.
Monitor
serum levels and adjust dose as appropriate.
Amitriptyline (Elavil); Tricyclic Antidepressant; Tab: 10, 25, 50, 75, 100, 150 mg;
Depression: 1-1.5 mg/kg/day PO qhs-tid (max 150 mg/day)
Chronic Pain: 0.1 mg/kg/day PO qhs, titrate as needed to 0.5-2 mg/kg/day PO qhs
Therapeutic Serum Levels: For amitriptyline plus nortriptyline (active
metabolite) 100-250 ng/mL.
Anticholinergic
side effects include urinary retention and sedation.