The nephrotoxicity of aminoglycosides
appears to be potentiated by vancomycin
Concurrent use is therapeutically useful, but the risk of increased nephrotoxicity should be borne in mind. Therapeutic drug monitoring and regular assessment of renal
function is warranted.
Note that amiodarone has a long half-life
(25 to 100 days) so that interactions may occur for some time after amiodarone has been withdrawn.