The aminoglycosides are known to be nephrotoxic and many of their interactions occur as a result of this effect. Due to the number of known interactions with other nephrotoxic drugs (for examples see amphotericin, and ciclosporin), many manufacturers of other drugs with nephrotoxic effects, including tacrolimus, caution concurrent use.
It is advisable to monitor renal function in patients taking aminoglycosides, and it may be prudent to increase the frequency of this monitoring in patients taking other nephrotoxic drugs.
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