The
aminoglycosides are known to be
nephrotoxic and many of their interactions occur as a result of this effect. Due to the number of known interactions with other
nephrotoxic drugs (for examples see amphotericin, and ciclosporin), many manufacturers of other drugs with
nephrotoxic effects, including
tacrolimus, caution concurrent use.
It is advisable to monitor
renal function in patients taking aminoglycosides, and it may be prudent to increase the frequency of this monitoring in patients taking other
nephrotoxic drugs.