Although animal studies suggest an interaction between loop
diuretics such as
furosemide and
bumetanide and the aminoglycosides, the weight of
clinical evidence suggests that they do not normally increase either the nephrotoxicity or ototoxicity associated with the
aminoglycosides. It has been suggested that an interaction may occur if high-dose infusions of
furosemide are used.
Increased monitoring (e.g. of
renal function) would seem appropriate if high doses of
furosemide are given. The same precautions would seem to be appropriate with other loop
diuretics.