AMINOGLYCOSIDES AND DIURETICS - OTHER LOOP DIURETICS

Although animal studies suggest an interaction between loop diuretics such as furosemide and bumetanide and the aminoglycosides, the weight of clinical evidence suggests that they do not normally increase either the nephrotoxicity or ototoxicity associated with the aminoglycosides. It has been suggested that an interaction may occur if high-dose infusions of furosemide are used.
Increased monitoring (e.g. of renal function) would seem appropriate if high doses of furosemide are given. The same precautions would seem to be appropriate with other loop diuretics.
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