Nephrotoxicity is increased in some patients by the concurrent use of ciclosporin and amikacin, gentamicin or tobramycin. This interaction would be expected with all systemic aminoglycosides.
The concurrent use of ciclosporin and aminoglycosides should only be undertaken if the clinical benefit outweighs the risk of renal damage. Close monitoring of renal function and aminoglycoside levels is required.
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