A Anumberofpatientsdevelopednephrotoxicity,whichwasattributedtoamphoter-
icin B. Raised gentamicin or amikacin levels, without significant changes in
creatinine, were seen in children treated with amphotericin B.
Aminoglycosides are
nephrotoxic and it is generally recommended that they should be avoided with other
nephrotoxic drugs (such as amphotericin B). However, if concurrent use is essential it may be prudent to increase the
renal function and drug level monitoring that is advised during aminoglycoside therapy.