Aminoglutethimide markedly increases the clearance of tamoxifen and reduces its serum levels. Tamoxifen does not appear to affect aminoglutethimide levels.
Theoretically, the combination of an oestrogen antagonist such as tamoxifen and an aromatase inhibitor should provide additional benefit in the treatment of hormone-dependent cancers, however, no clinical studies have yet found this to be so. This interaction may partly explain this. It may be preferable to use these drugs sequentially rather than concurrently.
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