ALPROSTADIL (PGE1) (al-pross'ta-dil) Prostin VR Pediatric, Caverject, Muse, Edex Classifications: prostaglandin; Therapeutic: prostaglandin Prototype: Epoprostenol Pregnancy Category: C |
500 mcg/mL injection; 5 mcg/mL, 10 mcg/mL, 20 mcg/mL, 40 mcg/mL powder for injection; 125 mcg, 250 mcg, 500 mcg, 1000 mcg pellets
Preserves ductal patency by relaxing smooth muscle of ductus arteriosus. Alprostadil induces penile erection by relaxing the smooth muscles of the corpus cavernosum and dilating the cavernosal arteries and their penile arterioles. Sufficient rigidity of the penis also requires increased venous outflow resistance.
Preserves ductal patency by relaxing smooth muscle of ductus arteriosus. It induces penile rigidity and erection by penile blood engorgement.
Temporary measure to maintain patency of ductus arteriosus in infants with ductal-dependent congenital heart defects until corrective surgery can be performed. Also used in erectile dysfunction.
Ductus arteriosus respiratory distress syndrome (hyaline membrane disease); neonates with respiratory distress syndrome; hypersensitivity to alprostadil; patients with penile implants. Muse, Edex: Women, children, and newborns; lactation. Muse: Patients with urethral stricture, inflammation/infection of glans of penis, severe hypospadias, acute or chronic urethritis; sickle cell anemia or trait, thrombocytopenia, thrombocytosis; polycythemia, multiple myeloma.
Ductus arteriosus; bleeding tendencies; cardiovascular disease; erectile dysfunction; hypersensitivity to alprostadil; leukemia; penile anatomic deformations; patients on anticoagulants, vasoactive or antihypertensive drugs.
To Maintain Patency of Ductus Arteriosus Neonate: IV/Intraarterial/Intraaortic 0.050.1 mcg/kg/min, may increase gradually (max: 0.4 mcg/kg/min if necessary) Erectile Dysfunction of Vasculogenic, Psychogenic, or Mixed Etiology Adult: Intracavernosal Initiate with 2.5 mcg; if inadequate response, increase dose by 2.5 mcg. May then increase dose in 5- to 10-mcg increments until a suitable erection occurs, not exceeding 1 h in duration. Doses >60 mcg not recommended Erectile Dysfunction of Pure Neurogenic Etiology Adult: Intracavernosal Initiate with 1.25 mcg; if inadequate response, increase dose by 1.25 mcg, then increase by 2.5 mcg, may then increase dose in 5 mcg increments until a suitable erection occurs, not exceeding 1 h in duration. Doses >60 mcg not recommended |
Intravenous PREPARE: Continuous: ??Dilute 500 mcg alprostadil with NS or D5W to volume appropriate for pump delivery system.??Prepare fresh solution q24h. Discard unused portions.??A 500 mcg ampule diluted in 250 mL yields a concentration of 2 mcg/mL. ADMINISTER: Continuous: Infuse at rate of 0.050.1 mcg/kg/min up to a maximum of 0.4 mcg/kg/min. ??Reduce infusion rate immediately if arterial pressure drops significantly or if fever occurs.??Discontinue promptly, if apnea or bradycardia occurs. |
Assessment & Drug Effects
Ductus Arteriosus
Patient & Family Education
Erectile Dysfunction