ALPHA1-PROTEINASE INHIBITOR (HUMAN) ![]() (pro'ten-ase) ![]() Prolastin, Aralast, Zemaira Classifications: enzyme inhibitor; Therapeutic: enzyme inhibitor Pregnancy Category: C |
Prolastin: 25 mg/mL; Aralast: 16 mg/mL; Zemaira: 50 mg/mL
Alpha1-proteinase inhibitor (alpha1-PI; alpha1-antitrypsin) is extracted from plasma and used in patients with panacinar emphysema who have alpha1-antitrypsin deficiency. Alpha1-antitrypsin deficiency is a chronic, hereditary, and usually fatal autosomal recessive disorder that results in a slowly progressive, panacinar emphysema.
Prevents the progressive breakdown of elastin tissues in the alveoli, thus slowing panacinar emphysema progression.
Indicated for chronic replacement therapy in patients with alpha1-antitrypsin deficiency and demonstrable panacinar emphysema.
Individuals with selective IgA deficiencies; pregnancy (category C); lactation.
Patients with significant heart disease or other conditions that may be aggravated with slight increases in plasma volume. Safety and efficacy in children are not established.
Panacinar Emphysema Adult: IV 60 mg/kg once/wk |
Intravenous
PREPARE: IV Infusion: ??Warm unopened diluent and concentrate to room temperature.??Use the supplied, double needle transfer device to reconstitute with sterile water for injection (supplied by manufacturer) to yield a concentration of 20 mg/mL. ADMINISTER: IV Infusion: ?? Give within 3 h after reconstitution.??Give alone, without mixing with other agents.??Administer at rate of 0.08 mL/kg/min or more slowly as determined by response and comfort of the patient.?? Note: The recommended dosage takes about 30 min to administer to a 70 kg person. |
Assessment & Drug Effects
Patient & Family Education