The use of an alpha blocker with a diuretic may result in an additive hypotensive effect, but aside from first-dose hypotension, this usually seems to be a beneficial interaction in patients with hypertension. An increased incidence of dizziness has
been noted with the combination of terazosin and a diuretic. In patients with BPH, terazosin, with or without diuretics, had no additional antihypertensive effect in those with controlled blood pressure, but did reduce blood pressure in those with uncontrolled hypertension. Patients with congestive heart failure, who have had large doses of diuretics, should start prazosin treatment at the lowest dose.
No action needed unless hypotension becomes excessive.
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