ALPHA BLOCKERS AND CICLOSPORIN (CYCLOSPORINE)

Preliminary studies show that prazosin causes a small reduction in the glomerular filtration rate of kidney transplant patients taking ciclosporin.
There would seem to be no strong reasons for totally avoiding prazosin in patients taking ciclosporin, but the authors of the report point out that the fall in glomerular filtration rate makes prazosin a less attractive antihypertensive.