appears to increase the renal
excretion of the active metabolite
, while allopurinol
is thought to inhibit the metabolism
. Theoretically, the concurrent use of allopurinol
could lead to uric acid precipitation in the kidneys.
significance of these interactions appears to be minimal. Nevertheless, the UK manufacturer of allopurinol
recommends any reduction in efficacy
should be assessed in each case. For allopurinol
injection, the US manufacturer recom- mends a high urinary output of at least 2 litres daily, and the maintenance of neutral or slightly alkaline urine, to help prevent renal
precipitation of urates.