ALLOPURINOL AND PHENYTOIN

A case report describes phenytoin toxicity in a boy given allopurinol. Another study
found raised phenytoin levels in 2 of 18 patients given allopurino.
The clinical importance of this interaction is probably small, but bear it in mind in case of an unexpected response to treatment. Indicators of phenytoin toxicity include blurred vision, nystagmus, ataxia or drowsiness.
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