ALLOPURINOL AND NRTIS

Allopurinol increases didanosine absorption (69% rise in the maximum serum levels). In some patients the dosage of didanosine has been halved without the loss of antiviral efficacy.
If the dose of didanosine is not reduced, there is the potential for an increase in didanosine adverse effects. The UK manufacturer recommends close monitoring for adverse effects but the US manufacturer advises against concurrent use.
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