ALLOPURINOL AND DIURETICS

The thiazide diuretics may increase the incidence of hypersensitivity reactions (rash, vasculitis, hepatitis, eosinophilia, progressive renal impairment) in patients taking allopurinol, especially in the presence of renal impairment.
The clinical significance of this interaction is unclear. Remember that thiazides can cause hyperuricaemia.
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