ALLOPURINOL AND CICLOSPORIN (CYCLOSPORINE)

In isolated cases markedly raised ciclosporin levels have occurred in patients given allopurinol. However, two clinical studies found a trend towards lower ciclosporin levels with low-dose allopurinol.
This interaction is unconfirmed and of uncertain clinical significance. There is insufficient evidence to recommend increased monitoring, but be aware of the potential for an interaction in case of an unexpected response to treatment.
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