Classifications: alpha-adrenergic antagonist; Therapeutic: antagonist of alpha-1 receptors
Pregnancy Category: B
10 mg extended-release tablet
Alfuzosin is a short-acting, selective antagonist at alpha-1 receptors with a low incidence of hypotension and sexual dysfunction
at therapeutic doses. Alpha-1 receptors cause contraction of smooth muscle in the prostate, prostatic capsule, prostatic
urethra, bladder base, and bladder neck. Both alpha-1a (70%) and alpha-1b receptors exist in the prostate.
Blockade of alpha-1 receptors by alfuzosin causes smooth muscles in the bladder neck and prostate to relax, thereby reducing
pressure on the urethra and improving urine flow rate. This results in a reduction in BPH symptoms.
Treatment of symptomatic benign prostatic hypertrophy (BPH).
Hypersensitivity to alfuzosin; severe hepatic insufficiency; concurrent treatment with potent CYP3A4 inhibitors (e.g., ketoconazole,
itraconazole, and ritonavir); angina; QT prolongation.
Coronary artery disease, cardiac arrhythmias; hepatic disease; dizziness, light-headedness, orthostatic hypotension; pregnancy
Route & Dosage
|Benign Prostatic Hypertrophy
Adult: PO 10 mg q.d.
- Give immediately after same meal each day.
- Ensure that extended-release tablet is not crushed or chewed. It must be swallowed whole.
- Store at 15°30° C (59°86° F). Protect from light and moisture.
Adverse Effects (≥1%)Body as a Whole: Fatigue
, pain. CNS:
Dizziness, headache. GI:
Abdominal pain, dyspepsia, constipation
, nausea. Respiratory:
Upper respiratory infection
, pharyngitis. Urogenital:
Increased risk of hypotension with other antihypertensive agents
or sildenafil, vardenafil,
and tadalafil; ketoconazole, itraconazole, protease inhibitors
may increase alfuzosin levels and toxicity
49% when taken with food. Peak:
8 h. Metabolism:
In liver by CYP3A4. Elimination:
69% in feces, 24% in urine. Half-Life:
Assessment & Drug Effects
- Monitor CV status and BP, especially if on concurrent treatment with antihypertensive drugs or inhibitors of CYP3A4. See
- Check postural vital signs to evaluate for orthostatic hypotension within a few hours following administration.
- Withhold drug and report new or worsening angina to physician.
- Lab tests: Baseline and periodic LFTs.
Patient & Family Education
- Inform physician about all other prescription, nonprescription, or herbal drugs being taken.
- Make position changes slowly to minimize dizziness.
- Do not drive or engage in other hazardous activities until reaction to drug is known.
- Moderate or eliminate grapefruit juice consumption while on this drug.