ADENOSINE AND THEOPHYLLINE

Theophylline can inhibit the effects of adenosine infusions used in conjunction with radionuclide myocardial imaging. Theophylline may antagonise the effect of adenosine when used to treat supraventricular arrhythmias.
Theophylline, aminophylline and other xanthines should be avoided for 24 hours before using an adenosine infusion for radionuclide myocardial imaging. Adenosine bolus injections for the termination of paroxysmal supraventricular tachycardia may still be effective in patients taking xanthines. The usual dose schedule should be followed. However, note that adenosine has induced
bronchospasm and it has been suggested that adenosine should be avoided in patients with asthma, and used cautiously in those with obstructive pulmonary disease. Xanthines, such as intravenous aminophylline, may be used to terminate any persistent adverse effects of adenosine infusions given for myocardial imaging.
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