No clinically significant pharmacokinetic interaction appears to occur between aciclovir
. However, the manufacturers say that in renal
impair- ment there may be competition for tubular secretion and increased concentrations of both drugs may occur. This is also possible with valaciclovir. A case report describes neutropenia
in a patient taking valaciclovir with mycophenolate
No action is needed, but increased monitoring may be prudent in patients with reduced renal
is a rare adverse effect of valaciclovir alone. Nevertheless, bear the possibility of an interaction in mind should neutropenia
occur if mycophenolate
is also given.