does not normally seem to affect ciclosporin
levels nor worsen renal
function, but a very small number of cases of nephrotoxicity and increased ciclosporin
levels have been seen following concurrent use. Valaciclovir, a prodrug of aciclovir
, is expected to interact similarly.
The handful of cases where problems have arisen clearly indicate that renal
function should be well monitored if both drugs are given. The manufacturers of valaciclovir recommend that renal
function is closely monitored if high doses (more than 4 g daily) are given with ciclosporin