ACICLOVIR AND CICLOSPORIN (CYCLOSPORINE)

Aciclovir does not normally seem to affect ciclosporin levels nor worsen renal function, but a very small number of cases of nephrotoxicity and increased ciclosporin levels have been seen following concurrent use. Valaciclovir, a prodrug of aciclovir, is expected to interact similarly.
The handful of cases where problems have arisen clearly indicate that renal function should be well monitored if both drugs are given. The manufacturers of valaciclovir recommend that renal function is closely monitored if high doses (more than 4 g daily) are given with ciclosporin.
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