Large rises in urinary pH due to the concurrent use of acetazolamide
could cause the retention of quinidine, which could lead to quinidine toxicity
. Also note that hypokalaemia, which may rarely be caused by acetazolamide
, can increase the toxicity
of QT-prolonging drugs such as quinidine
Monitor the effects if acetazolamide
is started or stopped and adjust the quinidine
dosage as necessary. Also consider monitoring potassium to ensure it is within the accepted range.