Large rises in urinary pH due to the concurrent use of acetazolamide could cause the retention of quinidine, which could lead to quinidine toxicity. Also note that hypokalaemia, which may rarely be caused by acetazolamide, can increase the toxicity of QT-prolonging drugs such as quinidine.
Monitor the effects if acetazolamide is started or stopped and adjust the quinidine dosage as necessary. Also consider monitoring potassium to ensure it is within the accepted range.
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