ACETAZOLAMIDE AND PHENOBARBITAL

Severe osteomalacia and rickets have been seen in a few patients taking phenobarbital or primidone with acetazolamide. A marked reduction in serum primidone levels with a loss in seizure control has also been described in a very small number of patients.
The general importance of this interaction is unknown, but bear it in mind in case of an unexpected response to treatment.
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