There is some limited evidence that acetazolamide can cause a marked and rapid rise in ciclosporin serum levels (up to 6-fold in 72 hours), possibly accompanied by renal toxicity.
Ciclosporin levels and/or effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if acetazolamide is started or stopped. Adjust the dose of ciclosporin as necessary.
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