ACE INHIBITORS AND TRIMETHOPRIM

A Tworeportsdescribeserioushyperkalaemia,apparentlycausedbytheconcurrentuse
of trimethoprim and enalapril or quinapril, in association with renal impairment.
Trimethoprim or ACE inhibitors alone can cause hyperkalaemia, particularly with other factors such as renal impairment. Monitor potassium levels if this combin- ation is used in those with renal impairment.
Acetazolamide
Note that although hypokalaemia may occur with acetazolamide it is said to be transient and rarely clinically significant.
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