A Tworeportsdescribeserioushyperkalaemia,apparentlycausedbytheconcurrentuse
of
trimethoprim and enalapril or quinapril, in association with
renal impairment.
Trimethoprim or
ACE inhibitors alone can cause hyperkalaemia, particularly with other factors such as
renal impairment. Monitor potassium levels if this combin- ation is used in those with
renal impairment.
Acetazolamide
Note that although hypokalaemia may occur with
acetazolamide it is said to be transient and rarely clinically significant.