Oedema of the tongue, face, lips, neck and chest has been reported in patients taking sirolimus
with enalapril or ramipril
who had previously taken these ACE inhibitors
without any adverse effects.
Caution should be used when either starting an ACE inhibitor in a patient already taking sirolimus
or when starting sirolimus
in a patient taking an ACE inhibitor. Higher doses of both drugs may pose a greater risk.