ACE INHIBITORS AND SIROLIMUS

Oedema of the tongue, face, lips, neck and chest has been reported in patients taking sirolimus with enalapril or ramipril who had previously taken these ACE inhibitors without any adverse effects.
Caution should be used when either starting an ACE inhibitor in a patient already taking sirolimus or when starting sirolimus in a patient taking an ACE inhibitor. Higher doses of both drugs may pose a greater risk.
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