Oedema of the tongue, face, lips, neck and chest has been reported in patients taking
sirolimus with enalapril or
ramipril who had previously taken these
ACE inhibitors without any adverse effects.
Caution should be used when either starting an ACE inhibitor in a patient already taking
sirolimus or when starting
sirolimus in a patient taking an ACE inhibitor. Higher doses of both drugs may pose a greater risk.