Epoetin may cause hypertension and thereby reduce the effects of ACE inhibitors, and an additive hyperkalaemic effect is theoretically possible. ACE inhibitors appear to reduce the efficacy of epoetin, but any interaction may take many months to develop.
As the epoetin dosage is governed by response, no immediate intervention is necessary. Blood pressure should be routinely monitored in those taking epoetin, but increased monitoring of potassium levels may be warranted.
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